Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial Previous Article Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial 1,2,3,4 DESIGN rivaroxaban). Lancet Diabetes Anticoagulation plus either one or two antiplatelet agents may be associated with better safety outcomes in patients with non-valvular atrial fibrillation (AFib), according to the results of the PIONEER AF-PCI Trial presented Nov. 14 during AHA 2016 and simultaneously published in the New England Journal of Medicine. Mosenzon O, Blicher TM, Rosenlund S, et al. The PIONEER-AF-PCI trial is the largest RCT n=2124 to date comparing triple therapy with warfarin vs a DOAC (i.e. While noninferior to placebo for the primary MACE endpoint, the GLP-1 agonist was linked with a mortality benefit in patients with type 2 diabetes. Headline results from the PIONEER 6 trial of oral semaglutide demonstrate that the investigational GLP-1 receptor agonist is non-inferior to placebo with regard to major adverse cardiovascular events (MACE). The PIONEER 5 study was a multicenter, double-blind, randomized, placebo-controlled, phase 3a trial where 324 participants, age ≥ 18yrs, with type 2 diabetes, HbA1C 7.0-9.0% and moderate renal impairment (eGFR 30-59 mL 2 ... (UPDATED) An oral version of semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist currently available as a once-weekly injection, successfully cleared a cardiovascular safety hurdle in the PIONEER … Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial. It also compared dual therapy with rivaroxaban to triple therapy with warfarin. It was a randomised, double-blinded, placebo-controlled trial About PIONEER 6 and the PIONEER clinical trial programme PIONEER 6 was an event-driven, pre-approval cardiovascular outcomes trial for oral semaglutide. Oral Semaglutide and Cardiovascular Outcomes in Diabetes Safety data exist for subcutaneous semaglutide, a glucagon-like peptide-1 receptor agonist, but not for the oral form.

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